College football odds, picks, predictions for Week 13, 2020: Proven model backing Clemson, Indiana

NCAA Football: Texas A&M at Alabama
Gary Cosby Jr / USA TODAY Sports

Thanksgiving Week traditionally brings some of the best college football of the season, and while COVID-19 certainly will impact the Week 13 college football schedule, there are still plenty of big-time rivalry matchups to look forward to. The 2020 Iron Bowl features top-ranked Alabama hosting No. 22 Auburn in an SEC on CBS matchup at 3:30 p.m. ET on Saturday. The latest Week 12 college football odds from William Hill Sportsbook list the Crimson Tide as 23-point favorites.

Also in the SEC, two of the biggest personalities in the sport meet up in the 2020 Egg Bowl as Lane Kiffin and the Ole Miss Rebels are laying 10 points in the latest college football spreads against Mike Leach and the Mississippi State Bulldogs. Those are just a couple of the rivalry matchups to consider making a play on in your Week 13 college football bets. Before making any Week 13 college football picks on those games or others, be sure to see the latest college football predictions and betting advice from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $3,600 for $100 players on its top-rated college football picks against the spread. It is a sizzling 44-23 on all top-rated picks through 12 weeks of the 2020 college football season, returning over $1,200 in profit already. Anybody who has followed it is way up.

Now, it has turned its attention to the latest college football odds for Week 13 from William Hill and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 13 college football predictions

One of the top Week 13 college football picks the model is recommending: No. 4 Clemson (-26.5) covers against Pittsburgh in a 3:30 p.m. ET matchup on Saturday. Trevor Lawrence is set to play in his first game since Oct. 24. The Heisman contender missed two games due to COVID-19, and then saw Clemson’s matchup against Florida State scrapped a few hours before kickoff last week.

Pittsburgh, meanwhile, has won two straight, but got blasted 45-3 against Notre Dame on Oct. 24. Clemson will be looking for style points too as the Tigers hope to impress the College Football Playoff committee. The model shows Lawrence throwing for over 250 yards and two touchdowns as the Tigers get the cover almost 60 percent of the time.

Another one of the top Week 13 college football predictions from the model: No. 12 Indiana (-14) covers at home in a noon ET kickoff against Maryland on Saturday. The Hoosiers took their first loss of the season last week against Ohio State, but it was still an impressive showing as they stormed back to make it competitive in the 42-35 final. That helped them easily stay within the spread as 21-point underdogs.

Indiana is now 5-0 against the spread this season. The model says that Indiana quarterback Michael Penix Jr. throws for well over 300 yards as the Hoosiers cover over 60 percent of the time.

How to make Week 13 college football picks

The model has also made the call on who wins and covers in the huge SEC on CBS showdown between No. 1 Alabama and No. 22 Auburn and every other Week 13 FBS matchup, and it is also predicting a major upset in the Big 12. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence in Week 13? And which Big 12 underdog will pull off a shocking upset? Check out the latest Week 13 college football odds for some of the week’s most notable games below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,900 in profit over the past four-plus seasons, and find out.

Week 13 college football odds (via William Hill)

Thursday, Nov. 26

Colorado State vs. Air Force (-6.5)

New Mexico vs. Utah State (+4.5)

Friday, Nov. 27

Iowa State vs. Texas (-2)

Nebraska vs. Iowa (-13.5)

Notre Dame vs. North Carolina (+5)

Oregon vs. Oregon State (+13)

Saturday, Nov. 28

Penn State vs. Michigan (-2)

Ohio State vs. Illinois (+28)

Kentucky vs. Florida (-24)

Maryland vs. Indiana (-14)

Minnesota vs. Wisconsin (-21.5)

Pittsburgh vs. Clemson (-26.5)

Northwestern vs. Michigan State (+11.5)

Colorado vs. USC (-13.5)

Auburn vs. Alabama (-23)

Mississippi State vs. Ole Miss (-10)

LSU vs. Texas A&M (-14)

Georgia vs. South Carolina (+19.5)

Oklahoma vs. West Virginia (+10.5)

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